Annals of Indian Academy of Neurology
  Users Online: 6900 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
Year : 2006  |  Volume : 9  |  Issue : 1  |  Page : 25-31

Profiles of language impairment in progressive nonfluent aphasia

Department of Neurology, Cognition and Behavioural Neurology Centre (CBNC), Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Trivandrum - 695011, Kerala, India

Correspondence Address:
P S Mathuranath
Department of Neurology, SCTIMST, Trivandrum - 695 011, Kerala
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.22818

Rights and Permissions

Objective: To study language in noncaucasian patients with progressive nonfluent aphasia (PNA). To determine differences in the language impairment in PNA patients with and without early onset behavioral changes. Materials and Methods: Based on clinical evaluation, six PNA patients were divided into those with ( EB , n =2) and without ( NB , n =4) early onset (i.e., within 24 months from onset) behavioural symptoms of frontotemporal dementia (FTD). NB was sub-grouped as Moderate (language plus subtle cognitive dysfunction; n =2) and Mild (isolated language dysfunction; n =2). Language on the western aphasia battery (WAB) of NB was compared with that of EB and of the three groups were compared with that of controls. Clinical follow-up ranged between 24 and 60 months from onset. Results: Three categories were matched for the disease duration. Compared to controls, significantly (P <0.05) lower scores were seen for all three groups on WAB fluency, repetition and writing; for the Moderate and EB on reading, naming and comprehension; and for the EB alone on information content. Information content and comprehension were significantly lower for the EB when compared to the NB. Over comparable periods, the aphasia quotient of patients in EB declined by more than 30 points and in the Moderate by 3 points. Conclusions: PNA frequently shows behavioral features suggestive of FTD early in the course of the illness. Poor information content on WAB differentiates patients with early behavioral dysfunction from those without. The extent of language impairment is a function of the disease stage rather than of disease duration, suggesting thereby that the "initial 2 years of relatively isolated language disorder" criteria, while useful, may exclude some patients with PNA.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded296    
    Comments [Add]    

Recommend this journal