Annals of Indian Academy of Neurology
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Year : 2006  |  Volume : 9  |  Issue : 2  |  Page : 127

Carbamazepine-induced sinus nodal dysfunction

Cochin, India

Correspondence Address:
D V Nair
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.25991

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How to cite this article:
Nair D V. Carbamazepine-induced sinus nodal dysfunction. Ann Indian Acad Neurol 2006;9:127

How to cite this URL:
Nair D V. Carbamazepine-induced sinus nodal dysfunction. Ann Indian Acad Neurol [serial online] 2006 [cited 2021 May 18];9:127. Available from:


I read with interest, the case report on Carbamazepine-induced sinus nodal dysfunction,[1] in your last issue. The authors have made a pertinent point about the potential risk of sinus node while treating patients with Carbamazepine. This adverse effect of Carbamazepine had been reported much earlier. Yet, it had perhaps not caught the attention of many clinicians who prescribe it for epilepsy, neuralgias and other diseases. As the authors have pointed out, the risk of sinus node dysfunction is greater with higher doses and elderly, but the same can occur even at lower doses also. There can be a diagnostic dilemma when the patients present with episodic loss of consciousness, when a differential diagnosis of complex absence seizure and syncopal attacks are to be entertained. During my practice, I have come across several patients with cardiogenic syncope, who were being treated with anti epileptic drugs under the erroneous diagnosis of complex absence. A detailed history and moment-by-moment description of the event and its settings can help the clinician to reach the right diagnosis. This report highlights the need to subject such patients and others who develop syncope like symptoms while on anti epileptic drugs, to detailed cardiological evaluation including ECG and holter-monitoring, in order to identify potentially fatal cardiac arrhythmias.

  References Top

1.Namboodiri NK, Bohora S, Tharakan JA. Carbamazepine-induced sinus nodal dysfunction. Ann Indian Acad Neurol 2006;9:36-9.  Back to cited text no. 1    


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