Annals of Indian Academy of Neurology
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Year : 2010  |  Volume : 13  |  Issue : 1  |  Page : 57-60

Preliminary report of directly observed treatment, short course in tuberculous meningitis

Department of Neurology, Medical College, Thiruvananthapuram, India

Correspondence Address:
Thomas Iype
Department of Neurology, Medical College, Thiruvananthapuram
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.61279

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Background: Diagnosis of tuberculous meningitis (TBM) is a challenge because of the manifold clinical presentation, and diagnosis is often delayed. Objectives: We wanted to share our experience of directly observed treatment short course (DOTS) in TBM. We did a retrospective analysis to look at the presentation, management and outcome of TBM patients from November 2006 to April 2008. Materials and Methods: TBM was diagnosed based on clinical criteria. We excluded patients with HIV. Results: We had 11 patients on DOTS regime. One died following hepatitis and another patient died of unrelated gastroenteritis. The only patient on daily regime died. Our patients generally presented late, at a median duration 20 days from onset of symptoms, and 50% had stage 3 disease at presentation. The median delay in diagnosis was 4.5 days. Discussion: We found DOTS to be effective in TBM but not without side effects.

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