Annals of Indian Academy of Neurology
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Year : 2012  |  Volume : 15  |  Issue : 4  |  Page : 313-314

Olanzapine-induced electroencephalographic changes reversed by lamotrigine

Deparment of Neurology, UT Health Science Center at Houston, Houston, TX, USA

Correspondence Address:
Prasuna L Velur
Department of Neurology, Texas Comprehensive Epilepsy Program, 6431 Fannin Street, MSB 7.102, Houston, TX 77030
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.104345

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The atypical neuroleptic, olanzapine (OLZ), may induce electroencephalographic (EEG) abnormalities. The anticonvulsant, lamotrigine (LMG), reduces interictal epileptiform discharges and is effective in seizures in patients with both primary and partial epilepsy syndromes. The effect of LMG on neuroleptic-induced EEG abnormalities has not been previously reported. We describe the case of a 13-year-old male with paroxysmal nonepileptic spells who underwent diagnostic video-EEG telemetry, whose abnormal OLZ-induced EEG findings were strikingly affected by LTG withdrawal and reintroduction. The effect of LTG in normalizing EEG changes in suspected epilepsy caused by atypical neuroleptics is discussed.

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