Annals of Indian Academy of Neurology
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Year : 2014  |  Volume : 17  |  Issue : 1  |  Page : 128-129

Vogt-Koyanagi-Harada syndrome presenting with encephalopathy

1 Infectious and Tropical Diseases Department, Isfahan University of Medical Sciences, Isfahan, Iran
2 Neurology Department, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Alireza E Naeini
No.106, Razi Medical building, Shams abadi St. Isfahan, 8134776514
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.128585

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Vogt-Koyanagi-Harada (VKH) is a rare syndrome affecting tissues containing melanocytes. The possibility of its autoimmune pathogenesis is supported by high frequent HLA-DR4 presentation, commonly associated with other autoimmune diseases. Eyes are the main affected organs, resulting in blindness. Brain disease is a late-onset event, and is extremely rare. Here, we are reporting a 57-year-old woman, a known case of VKH syndrome, presenting with brain encephalopathy several decades after the initial presentation. We think this long period between initial presentation and presentation of encephalopathy due to VKH syndrome has not been described before. She was treated with corticosteroids and discharged home with a good general condition.

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