Intergenotypic variation of Vitamin B12 and Folate in AD: In north Indian population

Neelam Chhillar; Neeraj Kumar Singh; Basu Dev Banerjee; Kiran Bala; Mitra Basu; Deepika Sharma

doi:10.4103/0972-2327.138510


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ORIGINAL ARTICLE

Year : 2014 | Volume : 17 | Issue : 3 | Page : 308-312

Intergenotypic variation of Vitamin B12 and Folate in AD: In north Indian population

Neelam Chhillar¹, Neeraj Kumar Singh¹, Basu Dev Banerjee², Kiran Bala³, Mitra Basu⁴, Deepika Sharma¹
¹ Department of Neurochemistry,Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi, India
² Environmental Biochemistry Laboratory, University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi, Dilshad Garden, Delhi, India
³ Department of Neurology, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi, India
⁴ Health Centre, Institute of Nuclear Medicine and Allied Science, Defence Research and Development Organisation, Timarpur, Delhi, India

Correspondence Address:
Deepika Sharma
Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences, Dilshad Garden - 110 095, Delhi
India

Source of Support: We are grateful to the Indian Council of Medical Research (ICMR), New Delhi, India, for the fi nancial assistance during the study as Senior Research Fellow, Conflict of Interest: None

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DOI: 10.4103/0972-2327.138510

Objectives: Changes in lifestyle habits such as diet modification or supplementation have been indicated as probable protective factors for a number of chronic conditions including Alzheimer's disease (AD). With this background, we aim to hypothesize that whether C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene contributes towards the risk of developing AD and its association with vitamin B12 and folate levels. Materials and Methods: A case-control study comprising of total 200 subjects, within the age group of 50-85 years. Their blood samples were analyzed for serum folate, vitamin B12 levels, and MTHFR C677T polymorphism by restriction fragment length polymorphism (RFLP). Results: The mean plasma levels of vitamin B12 and folate were significantly lower in study group when compared to the control group (P < 0.001). Genotypic and allelic frequency of MTHFR gene in both groups was found to be significant (P < 0.05). The intergenotypic variations of vitamin B12 and folate were found to be significant (P < 0.001). Conclusion: We concluded that the subjects with homozygous mutated alleles are more prone to AD and also pointed out the influence of presence/absence of MTHFR T allelic variants on serum folate and vitamin B12 levels.

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