Annals of Indian Academy of Neurology
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Year : 2016  |  Volume : 19  |  Issue : 3  |  Page : 388-391

Hemi-meningitis with hemophagocytic lymphohistiocytosis

1 Department of Pediatric Neurology, Eskisehir Osmangazi University Hospital, Eskisehir, Turkey
2 Department of Pediatric Neurology, Eskişehir State Hospital, Eskisehir, Turkey
3 Department of Pediatric Neurology, Bursa Sevket Yilmaz Education and Research Hospital, Bursa, Turkey
4 Department of Pediatric Hematology, Eskisehir Osmangazi University Hospital, Eskisehir, Turkey

Correspondence Address:
Ozan Kocak
Department of Pediatric Neurology, Eskisehir Osmangazi University Hospital, Meselik, Eskisehir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.165458

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Hemophagocytic lymphohistiocytosis (HLH) is a rare lymphoproliferative disorder. HLH may occur as a complication of Epstein-Barr virus (EBV), particularly in patients with immunodeficiencies. Herein, we describe a 16-year-old girl with neurological complications associated EBV-induced HLH. Her cerebral magnetic resonance imaging (MRI) showed contrast-enhanced axial T1-weighted images with enhancement of meningeal surface in the right hemisphere that was consistent with right hemi-meningitis. Hydrocephalus, dilated subdural spaces, delayed myelination, edema, diffuse parenchymal atrophy, calcifications, diffuse/patchy white matter abnormalities have all been previously described with HLH. To the best of our knowledge, this is the first case of hemi-meningitis associated with HLH. We suggest that clinicians should consider HLH with vascular disorders when they determine unilateral meningitis on a brain MRI.

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