BRIV_adv
Annals of Indian Academy of Neurology
  Users Online: 205 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
CASE REPORT
Year : 2021  |  Volume : 24  |  Issue : 2  |  Page : 239-242

Unabridged histoplasmosis myositis: Unsolved dissemination with diagnostic challenge


1 MBBS Student, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
2 Intern, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
3 Department of Chest, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
4 Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
5 Department of Critical Care Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India

Correspondence Address:
Dr. Birinder S Paul
114 B Block BRS Nagar, Ferozpur Road, Ludhiana, Punjab - 141 001
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aian.AIAN_511_20

Rights and Permissions

Histoplasmosis occurs predominantly in immunocompromised hosts and typically presents with mild constitutional symptoms, weight loss, weakness, fatigability, hepatosplenomegaly, and lymphadenopathy. The diagnosis is generally delayed and is based upon isolating the organism in blood cultures or by identifying intracellular organisms in tissues. Disseminated Histoplasmosis is well described in HIV patients but Histoplasmosis myositis is a rare manifestation and has not been reported in seronegative patients till date. We here address a case of a pharmacologically immunosuppressed patient with extensive Histoplasmosis myositis invading almost all the skeletal muscles of body (including plantar foot muscles) with no evidence of dissemination to other organ-systems. Clinical examination and investigations co-related with infiltrative muscle disease and skeletal muscle biopsy revealed Histoplasma capsulatum. This patient illustrates a distinctive clinical presentation of fungal infection with subtle constitutional symptoms and isolated muscle weakness which added to the diagnostic challenge. Hence, differential diagnosis of fungal infection must always be considered as a cause of myopathy in any pharmacologically immunosuppressed patient.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed711    
    Printed28    
    Emailed0    
    PDF Downloaded44    
    Comments [Add]    

Recommend this journal