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LETTERS TO THE EDITOR
Year : 2021  |  Volume : 24  |  Issue : 4  |  Page : 620
 

Clinical presentation and outcome of children with brain abscess: Author's reply


1 Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
2 Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Date of Submission09-Aug-2020
Date of Acceptance09-Aug-2020
Date of Web Publication19-Jan-2021

Correspondence Address:
Dr. Ankur Singh
Associate Professor, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aian.AIAN_859_20

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How to cite this article:
Prasad R, Biswas J, Singh K, Mishra OP, Singh A. Clinical presentation and outcome of children with brain abscess: Author's reply. Ann Indian Acad Neurol 2021;24:620

How to cite this URL:
Prasad R, Biswas J, Singh K, Mishra OP, Singh A. Clinical presentation and outcome of children with brain abscess: Author's reply. Ann Indian Acad Neurol [serial online] 2021 [cited 2021 Oct 28];24:620. Available from: https://www.annalsofian.org/text.asp?2021/24/4/620/307435




To The Editor

I would like to thank the reader for showing interest in my article.[1] I agree with comments given by reader. We would have definitely improved our observation and knowledge by analyzing the factors (Both clinical and radiological) related to the outcome of brain abscess in our cohort. Since data was not collected in that manner, we did not analyze it. We will incorporate your advice in our future studies. Information regarding type of seizure, antiepileptic drug used, and electroencephalographic abnormalities were not collected; thus, this information cannot be provided. As this cohort was not followed for long, the data regarding the number of patients developing epilepsy was not collected. All our patients were seizure free at discharge and we were able to stop in follow-up next 3 months. Seven patients required the management of raised intracranial tension and four patients had established papilledema. Antibiotic change was required in only five patients based on culture sensitivity report. Proteus mirabilis (n-2) was sensitive to amoxicillin-clavulanic acid, gentamicin, amikacin, and piperacillin-tazobactam, ceftazidime, and resistant to ampicillin, ceftriaxone, cefotaxime, and fluoroquinolones. We have not analyzed our outcome based on culture sensitivity report as there were only five cases in culture-positive group and this may have yielded spurious results. Factors like chronic paranasal sinusitis, orbital cellulitis, dental infection, history of penetrating head injury, presence of malignancy, or use of immunosuppressants were not present in this cohort. We could not do a full set of investigations for immunodeficiency except immunoglobulin profile due to lack of funding. We have mentioned this in our limitation to the study. Levels of immunoglobulin (IgA, IgG, IgM, and IgE) were in normal range for age and sex. Open craniotomy followed by aspiration was done in six cases. Indications in our cohort were failure of burr hole aspiration in five cases and fungal abscess in one case.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Prasad R, Biswas J, Singh K, Mishra OP, Singh A. Clinical profile and outcome of brain abscess in children from a tertiary care hospital in Eastern Uttar Pradesh. Ann Indian Acad Neurol 2020;23:303-7.  Back to cited text no. 1
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