Annals of Indian Academy of Neurology
  Users Online: 2148 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2022  |  Volume : 25  |  Issue : 6  |  Page : 1116-1121

Impact of COVID-19 on guillain-barre syndrome in India: A multicenter ambispective cohort study


1 Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
2 Post Graduate Institute of Medical Education and Research, Chandigarh, India
3 National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India
4 Krishna Institute of Medical Sciences Hospital, Secunderabad, Telangana, India
5 Dayanand Medical College, Ludhiana, Punjab, India
6 All India Institute of Medical Sciences, New Delhi, India
7 Lady Hardinge Medical College, New Delhi, India
8 Government Medical College Kozhikode, Kerala, India
9 Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
10 Government Medical College, Thiruvananthapuram, Kerala, India
11 Apollo Hospitals, Sheshadripuram, Bangalore, India
12 PBM Hospital, Sardar Patel Medical College, Bikaner, India
13 Indira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, India
14 All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
15 Shree Krishna Hospital and Pramukhswami Medical College, Bhaikaka University, Karamsad, Anand, Gujarat, India
16 Kalinga Hospital Limited, Bhubaneswar, Odisha, India
17 Apollo Gleneagles Hospitals, Kolkata, West Bengal, India
18 Lalitha Super Specialities Hospital Private Limited, Guntur, Andhra Pradesh, India
19 Goa Medical College, Goa, India
20 Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
21 NH MMI Narayana Superspeciality Hospital, Raipur, Chattisgarh, India
22 All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
23 Caritas Hospital, Kottayam, Kerala, India
24 Ramakrishna Care Medical Sciences Private Limited, Raipur, India
25 Pondicherry Institute of Medical Sciences, Pondicherry, India
26 Army Hospital, Guwahati, Assam, India

Correspondence Address:
Venugopalan Y Vishnu
Department of Neurology, MRC International Fellow in Neuromuscular Genomic Medicine, Room No. 704, CN Centre, Seventh Floor, All India Institute of Medical Sciences, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aian.aian_523_22

Rights and Permissions

Introduction/Aims: Studies conducted during the coronavirus disease 2019 (COVID-19) pandemic have reported varied data regarding the incidence of Guillain–Barre syndrome (GBS). The present study investigated demographic and clinical features, management, and outcomes of patients with GBS during a specified period of the COVID-19 pandemic, and compared these features to those of GBS in the previous year. Methods: A multicenter, ambispective cohort study including 26 centers across India was conducted. Data from a pre-COVID-19 period (March 1 to August 31, 2019) were collected retrospectively and collected ambispectively for a specified COVID-19 period (March 1 to August 31, 2020). The study was registered with the Clinical Trial Registry India (CTRI/2020/11/029143). Results: Data from 555 patients were included for analysis: pre-COVID-19 (n = 334) and COVID-19 (n = 221). Males were more commonly affected during both periods (male:female, 2:1). Gastroenteritis was the most frequent antecedent event in 2019 (17.4%), whereas fever was the most common event in 2020 (10.7%). Paraparesis (21.3% versus [vs.] 9.3%, P = 0.001) and sensory involvement (51.1% vs. 41.3%; P = 0.023) were more common during COVID-19 in 2020, whereas back pain (26.3% vs. 18.4%; P = 0.032) and bowel symptoms (20.7% vs. 13.7%; P = 0.024) were more frequent in the pre-COVID period. There was no difference in clinical outcomes between the two groups in terms of GBS disability score at discharge and 3 months after discharge. Independent predictors of disability in the pre-COVID period included areflexia/hyporeflexia, the requirementfor intubation, and time to bulbar weakness; in the COVID-19 period, independent predictors included time from onset to admission, intubation, and intubation requirement. The mortality rate was 2.3% during the entire study period (13/555 cases). Discussion: Results of this study revealed an overall reduction in the frequency of GBS during the pandemic. The lockdown likely reduced the risk for antecedent infections due to social distancing and improved hygiene, which may have resulted in the reduction of the frequency of GBS.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed364    
    Printed12    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal