Impact of COVID-19 on guillain-barre syndrome in India: A multicenter ambispective cohort study

Yareeda Sireesha; Ritu Shree; Madhu Nagappa; Anuja Patil; Monika Singla; MV Padma Srivastava; RK Dhamija; Neetha Balaram; Abhishek Pathak; Dileep Ramachandran; Sujit Kumar; Inder Puri; Sudhir Sharma; Samhita Panda; Soaham Desai; Priyanka Samal; Aditya Choudhary; Pamidimukkala Vijaya; Teresa Ferreira; SS Nair; HP Sinha; SK Bhoi; Joseph Sebastian; Sanjay Sharma; Aneesh Basheer; Manish Bhartiya; NL Mathukumalli; Shaikh Afshan Jabeen; Vivek Lal; Manish Modi; P Praveen Sharma; Subash Kaul; Gagandeep Singh; Ayush Agarwal; Divyani Garg; James Jose; Priya Dev; Thomas Iype; Maya Gopalakrishnan; Ashish Upadhyay; Rohit Bhatia; Awadh K Pandit; Rajesh K Singh; Manish Salunkhe; PM Yogeesh; Alisha Reyaz; Nishant Nadda; Menkha Jha; Bismay Kumar; PK Kushwaha; Harshadkumar Chovatiya; Bhavani Madduluri; P Ramesh; Abeer Goel; Rahul Yadav; Venugopalan Y Vishnu

doi:10.4103/aian.aian_523_22


Users Online: 2148	Home \| About the Journal \| Instructions \| Current Issue \| Back Issues \| Login

ORIGINAL ARTICLE

Year : 2022 | Volume : 25 | Issue : 6 | Page : 1116-1121

Impact of COVID-19 on guillain-barre syndrome in India: A multicenter ambispective cohort study

Yareeda Sireesha¹, Ritu Shree², Madhu Nagappa³, Anuja Patil⁴, Monika Singla⁵, MV Padma Srivastava⁶, RK Dhamija⁷, Neetha Balaram⁸, Abhishek Pathak⁹, Dileep Ramachandran¹⁰, Sujit Kumar¹¹, Inder Puri¹², Sudhir Sharma¹³, Samhita Panda¹⁴, Soaham Desai¹⁵, Priyanka Samal¹⁶, Aditya Choudhary¹⁷, Pamidimukkala Vijaya¹⁸, Teresa Ferreira¹⁹, SS Nair²⁰, HP Sinha²¹, SK Bhoi²², Joseph Sebastian²³, Sanjay Sharma²⁴, Aneesh Basheer²⁵, Manish Bhartiya²⁶, NL Mathukumalli¹, Shaikh Afshan Jabeen¹, Vivek Lal², Manish Modi², P Praveen Sharma³, Subash Kaul⁴, Gagandeep Singh⁵, Ayush Agarwal⁶, Divyani Garg⁷, James Jose⁸, Priya Dev⁹, Thomas Iype¹⁰, Maya Gopalakrishnan¹⁴, Ashish Upadhyay⁶, Rohit Bhatia⁶, Awadh K Pandit⁶, Rajesh K Singh⁶, Manish Salunkhe⁶, PM Yogeesh⁶, Alisha Reyaz⁶, Nishant Nadda¹³, Menkha Jha²², Bismay Kumar⁹, PK Kushwaha²¹, Harshadkumar Chovatiya¹⁵, Bhavani Madduluri¹, P Ramesh¹, Abeer Goel², Rahul Yadav¹⁵, Venugopalan Y Vishnu⁶
¹ Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
² Post Graduate Institute of Medical Education and Research, Chandigarh, India
³ National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India
⁴ Krishna Institute of Medical Sciences Hospital, Secunderabad, Telangana, India
⁵ Dayanand Medical College, Ludhiana, Punjab, India
⁶ All India Institute of Medical Sciences, New Delhi, India
⁷ Lady Hardinge Medical College, New Delhi, India
⁸ Government Medical College Kozhikode, Kerala, India
⁹ Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
¹⁰ Government Medical College, Thiruvananthapuram, Kerala, India
¹¹ Apollo Hospitals, Sheshadripuram, Bangalore, India
¹² PBM Hospital, Sardar Patel Medical College, Bikaner, India
¹³ Indira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, India
¹⁴ All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
¹⁵ Shree Krishna Hospital and Pramukhswami Medical College, Bhaikaka University, Karamsad, Anand, Gujarat, India
¹⁶ Kalinga Hospital Limited, Bhubaneswar, Odisha, India
¹⁷ Apollo Gleneagles Hospitals, Kolkata, West Bengal, India
¹⁸ Lalitha Super Specialities Hospital Private Limited, Guntur, Andhra Pradesh, India
¹⁹ Goa Medical College, Goa, India
²⁰ Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
²¹ NH MMI Narayana Superspeciality Hospital, Raipur, Chattisgarh, India
²² All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
²³ Caritas Hospital, Kottayam, Kerala, India
²⁴ Ramakrishna Care Medical Sciences Private Limited, Raipur, India
²⁵ Pondicherry Institute of Medical Sciences, Pondicherry, India
²⁶ Army Hospital, Guwahati, Assam, India

Correspondence Address:
Venugopalan Y Vishnu
Department of Neurology, MRC International Fellow in Neuromuscular Genomic Medicine, Room No. 704, CN Centre, Seventh Floor, All India Institute of Medical Sciences, New Delhi
India

Source of Support: None, Conflict of Interest: None

Check

DOI: 10.4103/aian.aian_523_22

Introduction/Aims: Studies conducted during the coronavirus disease 2019 (COVID-19) pandemic have reported varied data regarding the incidence of Guillain–Barre syndrome (GBS). The present study investigated demographic and clinical features, management, and outcomes of patients with GBS during a specified period of the COVID-19 pandemic, and compared these features to those of GBS in the previous year. Methods: A multicenter, ambispective cohort study including 26 centers across India was conducted. Data from a pre-COVID-19 period (March 1 to August 31, 2019) were collected retrospectively and collected ambispectively for a specified COVID-19 period (March 1 to August 31, 2020). The study was registered with the Clinical Trial Registry India (CTRI/2020/11/029143). Results: Data from 555 patients were included for analysis: pre-COVID-19 (n = 334) and COVID-19 (n = 221). Males were more commonly affected during both periods (male:female, 2:1). Gastroenteritis was the most frequent antecedent event in 2019 (17.4%), whereas fever was the most common event in 2020 (10.7%). Paraparesis (21.3% versus [vs.] 9.3%, P = 0.001) and sensory involvement (51.1% vs. 41.3%; P = 0.023) were more common during COVID-19 in 2020, whereas back pain (26.3% vs. 18.4%; P = 0.032) and bowel symptoms (20.7% vs. 13.7%; P = 0.024) were more frequent in the pre-COVID period. There was no difference in clinical outcomes between the two groups in terms of GBS disability score at discharge and 3 months after discharge. Independent predictors of disability in the pre-COVID period included areflexia/hyporeflexia, the requirementfor intubation, and time to bulbar weakness; in the COVID-19 period, independent predictors included time from onset to admission, intubation, and intubation requirement. The mortality rate was 2.3% during the entire study period (13/555 cases). Discussion: Results of this study revealed an overall reduction in the frequency of GBS during the pandemic. The lockdown likely reduced the risk for antecedent infections due to social distancing and improved hygiene, which may have resulted in the reduction of the frequency of GBS.

[FULL TEXT] [PDF]*

Table of Contents

Similar in PUBMED

Search Pubmed for

Search in Google Scholar for

Related articles

Citation Manager

Access Statistics

Reader Comments

Email Alert *

Add to My List *

* Requires registration (Free)

Article Access Statistics

Viewed	364

Printed	12

Emailed	0

PDF Downloaded	53

Comments	[Add]