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ORIGINAL ARTICLE
Year : 2022  |  Volume : 25  |  Issue : 6  |  Page : 1147-1152
 

Neuropsychiatric features, health-related quality of life, and caregiver burden in parkinson's disease


Department of Neurology, JIPMER, Puducherry, India

Date of Submission11-Jan-2022
Date of Decision03-Nov-2022
Date of Acceptance03-Nov-2022
Date of Web Publication3-Dec-2022

Correspondence Address:
Ramkumar Sugumaran
Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research, Gorimedu, Dhanvantri Nagar, Puducherry - 605 006
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aian.aian_38_22

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   Abstract 


Aim: Parkinson's disease (PD) is a progressive neurodegenerative disease and significantly impacts patients and their caregivers. The current study aims at recognizing its neuropsychiatric symptoms, its impact on the health-related quality of life (HRQOL) of the patients, and the caregiver burden in a middle- to-low-income country. Methods: We conducted a cross-sectional survey of 73 idiopathic Parkinson's disease (IPD) patients and their caregivers from January 2021 to June 2021. Neuropsychiatric Inventory (NPI-12) and Parkinson's disease questionnaire (PDQ-39) were used to assess patients' symptoms and HRQOL, respectively. We used the Zarit caregiver burden interview (ZBI) and Hamilton depression scale (Ham-D) for the caregiver's burden assessment. Results: Of the 73 patients, 43 (59%) were men, and 30 (41%) were women. Their mean age was 60.25 years (± 11.1), and the mean duration of PD was 6.4 years (± 3.4). Eighty-six percent of the patients reported having one or more neuropsychiatric symptoms. HRQOL, as indicated by PDQ-39, correlated most significantly with H and Y staging (r = 0.680, P < 0.001) of the disease. Sixty-eight percent of the caregivers felt a disease burden, and 55% had depression. On regression analysis, NPI total score on caregiver burden (beta = 0.883, P < 0.001, confidence interval [CI] of 1.087 to 1.400,) and H and Y staging on depression (beta = 0.772, P < 0.001, [CI of 0.629 to 0.934) were having the most decisive impact. Conclusion: Our study showed the presence of frequent neuropsychiatric symptoms in PD patients. It has a detrimental effect on the quality of life of patients and results in a significant increase in caregiver burden and depression among them.


Keywords: Caregiver burden, movement disorders, neuropsychiatric symptoms, Parkinson's disease, quality of life


How to cite this article:
Goel A, Narayan SK, Sugumaran R. Neuropsychiatric features, health-related quality of life, and caregiver burden in parkinson's disease. Ann Indian Acad Neurol 2022;25:1147-52

How to cite this URL:
Goel A, Narayan SK, Sugumaran R. Neuropsychiatric features, health-related quality of life, and caregiver burden in parkinson's disease. Ann Indian Acad Neurol [serial online] 2022 [cited 2023 Jan 29];25:1147-52. Available from: https://www.annalsofian.org/text.asp?2022/25/6/1147/361987





   Introduction Top


Parkinson's disease (PD) first description can be seen in “An Essay on the Shaking Palsy” by British Surgeon James Parkinson in 1817.[1] It is a progressive neurodegenerative disorder affecting patients mainly after the fifth decade of life. Pathologically, it is characterized by the loss of dopaminergic neurons in the substantia nigra. Traditionally, tremors, bradykinesia, rigidity, and postural instability are described as cardinal manifestations of PD. However, it is now widely recognized as a complex disorder with various clinical features, including non-motor and neuropsychiatric symptoms. Depression, anxiety, apathy, psychosis, hallucinations, sleep disturbances, agitation, and irritability are the prominent neuropsychiatric manifestations.[2] PD is often quite challenging to deal with all these manifestations, both for the patients and their caregivers.

With the disease's progressive nature, there is a progression of motor symptoms and the emergence and worsening of neuropsychiatric symptoms. This not only negatively impacts the patient but also their caregivers.[3] Most PD patients are taken care of at their homes, and most of the time, spouses, children, or friends are the informal caregivers. They provide support and assistance to patients in their medicine administration, fall surveillance, care coordination, and emotional support in a day-to-day routine. In addition to that, they have to bear the brunt of mood problems, psychosis, agitation, irritability, and sleep disturbances.

Moreover, they have to go through the tedious process of PD diagnosis to treatment and palliative care, accompanying the ailing patient. These everyday challenges faced by caregivers affect their physical, mental, and social well-being. The amount of these effects perceived by them can be defined as caregiver burden.

Most of the evidence of caregiver burden comes from high-income countries. However, people living in low- to middle-income countries have additional challenges due to insufficient healthcare facilities, lack of educational and social support, and limited capacity to spend money on healthcare. Additionally, there is insufficient time spent on the patients in the busy outpatient clinics due to limited healthcare staff. Most of the time, non-motor and psychiatric symptoms are ignored, further worsening the quality of life in PD patients. It is often challenging to address caregiver issues in this environment, and usually, their concerns remain unaddressed.

The current study aims to increase our understanding of caregiver burden in a middle- to low-income country concerning health-related quality of life and neuropsychiatric symptoms in PD patients.


   Subjects and Methods Top


We conducted a cross-sectional survey of caregivers and patients with idiopathic PD attending a neurology specialist outpatient clinic at a tertiary hospital in South India between January 2021 and June 2021. The study design and concept were approved by the JIEC (JIPMER institutional ethics committee - JIP/IEC/2020/279). A diagnosis of PD was established as per the criteria laid by the Movement Disorder Society Clinical Diagnostic Criteria for PD. Patients taking antidepressants, benzodiazepines, and antipsychotics, and receiving deep brain stimulation were excluded from the study. A sample size of 73 was calculated based upon the assumption of an 80% prevalence of neuropsychiatric symptoms, absolute precision of 6%, and confidence estimate of 80%. Caregivers were selected based on the predefined criteria that include a person close to the patient who assists him in daily activities or provides emotional support. The caregiver is required to spend at least three hours a day for more than six months. A caregiver belonging to a professional group or network was excluded from the study. Patients or caregivers who were unable to fill out questionnaires were excluded. Patients' and caregivers' demographic details including age, sex, duration, comorbidities, clinical history, and examination findings were noted in a pre-test format.

Neuropsychiatric Inventory (NPI-12) was used to assess the patient's symptoms. It comprises 12 different categories covering four major neuropsychiatric domains, including psychosis, agitation, apathy, and mood. The NPI is based on the responses from an informed caregiver. Symptom frequency was rated 1 to 4, and severity was rated 1 to 3. A composite score is calculated as the product of frequency and severity, ranging from 1 to 12. A total NPI score (0-144) was calculated after summing up all the composite scores.[4]

HRQOL was measured by Parkinson's disease-specific PDQ-39 questionnaire. It is a patient-reported measure of health status and quality of life. It consists of 39 questions on eight domains, including mobility, daily living activities, emotional well-being, stigma, social support, cognition, communications, and bodily discomfort. The score of each question ranges from 0 to 4 based on the frequency of symptoms (0 = never, 1 = occasionally, 2 = sometimes, 3 = often, 4 = always). Each domain score is calculated as a percentage and can range from 0 to 100, in which zero is the best score, and 100 is the worst quality of life.[5]

Caregiver burden was calculated using Zarit's caregiver burden (ZBI) and Hamilton depression scale (Ham-D). ZBI is a 22-item questionnaire for assessing caregiver stress related to patient disabilities. Each response is scored from 0 to 4, and the total ranges from 0 to 88, with a higher score, representing poor caregiver burden.[6] Ham-D is a 21-item scale that categorizes depression severity into mild, moderate, severe, and very severe depression.[7]

Statistical analyses

Demographics were described using the mean, standard deviation (SD), frequency, and percentage. Correlation analysis was done by Spearman's rank correlation for ordinal variables. Multiple linear regression analyses were performed to evaluate the effect of independent variables on caregiver burden. A P value <0.05 was considered significant. Statistical analyses were performed using SPSS software version 28.0 (SPSS Inc., Chicago, IL, USA).


   Results Top


In this study, we recruited 73 patients, 43 (59%) were men, and 30 (41%) were women. Their mean age (± SD) and mean duration of PD (± SD) were 60.25 (11.1) years and 6.4 (3.4) years, respectively. Sixteen patients (21.9%) had diabetes, 25 (34.2%) had hypertension, 9 (12.3%) had heart disease, and 8 (11%) had an abnormal lipid profile. The mean Hoehn and Yahr stage was 2.23 ± 1.04. 86% of the patients reported having one or more neuropsychiatric symptoms. The most common symptoms were sleep disturbance (50.7%), anxiety (32.9%), and depression (28.8%). We interviewed 145 caregivers for the 73 recruited patients. The mean age of the caregivers was 46.2 ± 14 years. Most of the caregivers were spouses (54.8%) and daughters (32%). Eighty-eight percent of the caregivers live with the patient, and 35% had access to domestic help. We found that only 11% of the caregivers were formally educated about the disease. 68.5% of the caregiver felt a burden, and 54.8% agreed to some form of depression [Table 1] and [Table 2].
Table 1: Demographic, clinical, and neuropsychological variables of patients and caregivers

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Table 2: Neuropsychiatric manifestations as per NPI scores

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Using Spearman's correlation coefficient, we assessed patient demographics, H and Y stage, and NPI-12 correlation with the patient's quality of life scale PDQ-39. Because of the large number of comparisons used, we applied the Bonferroni correction. For this part of the analysis, a P value of less than 0.029 was considered significant. Higher PDQ-39 total score correlated most significantly with greater disease severity as indicated by the H and Y scale (r = 0.680, P < 0.001), NPI total score (r = 0.466, P < 0.001), disease duration (r = 0.331, P < 0.001), presence of hallucination (r = 0.547, P < 0.001), delusions (r = 0.445, P = 0.016), and agitation (r = -0.374, P = 0.029). All the subdomains of PDQ-39 strongly correlated with H and Y staging. Except for activities of daily living, all subdomains are also strongly correlated with hallucinations. A greater number of caregivers were associated with improved quality of life as determined by PDQ-39 score (r = -0.303, P < 0.001) [Table 3].
Table 3: Spearman correlation coefficients of the PDQ-39 summary score, and subscores with the clinical and neuropsychological variables

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We performed multiple regression analysis with ZBI as a dependent factor and patient's age, duration of disease, number of caregivers, NPI domains, NPI total score, Hoehn and Yahr stage, and PDQ-39 as independent factors. Overall NPI total score was the best predictor of caregiver burden (beta = 0.883, P < 0.001, confidence interval [CI] of 1.087 to 1.400) followed by Hoehn and Yahr stage (beta = 0.711, P < 0.001, CI of 8.345 to 13.450) and PDQ-39 total score (beta = 0.676, P < 0.001, CI of 0.28 to 0.47). Among neuropsychiatric symptoms, hallucinations were the most significant predictor of caregiver burden (beta = 0.690, P < 0.001, confidence interval [CI] of 2.048 to 3.402). It was followed by delusion (beta = 0.690, P < 0.001, CI of 2.048 to 3.402) and agitation (beta = 0.493, P < 0.001, CI of 1.886 to 4.597). Other variables correlating significantly with caregiver burden were the higher age of the patient, longer duration of the disease, and all neuropsychiatric symptoms except apathy. More than two caregivers were significantly associated with a decreased caregiver burden (beta = -0.506, P < 0.001, CI of -22.8 to -9.7) [Table 4].
Table 4: Multiple regression analysis of dependent variable ZBI

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HAM-D was also used as a dependent variable for multiple regression analysis with independent variables the same as mentioned for ZBI. Hoehn and Yahr's stage was the most significant predictor of depression among caregivers (beta = 0.772, P < 0.001 [CI of 0.629 to 0.934). NPI total score, hallucinations, delusions, agitation, depression, anxiety, irritability, sleep problems, age, duration of disease, and PDQ-39 were other variables strongly associated with depression among caregivers. More than two caregivers were strongly associated with decreased depression scores (beta = -4.330, P < 0.001, [CI of -1.417 to -0.523) [Table 5].
Table 5: Multiple regression analysis of dependent variable Ham-D

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   Discussion Top


This study is one of the few clinical studies done in middle to low-income countries investigating HRQOL and neuropsychiatric symptoms in PD patients and its direct comparison with caregiver burden.

Out of 73 patients recruited, 86% reported having one or more neuropsychiatric symptoms. Sleep disturbances were the most common neuropsychiatric complaints. Frequent awakening in the night and early morning were the most common complaints. This finding is consistent with previous studies demonstrating that up to 80% of PD patients can have sleep disturbances.[8],[9] Anxiety and depression were the subsequent most common symptoms, in line with previous studies.[10]

In our study, a higher PDQ-39 score indicates that poor patient quality of life is most strongly associated with H and Y staging, duration of disease, and NPI score, in line with previous studies. However, in the NPI-12 domain, we found that hallucinations were most consistently associated with poor quality of life. In the previous studies, depression, anxiety, and apathy were reported as the most significant factor impacting a patient's quality of life. [3,11] This heterogeneity of our result could be due to longer disease duration in our patients, leading to more psychotic symptoms and thus, impacting the quality of life. Previously it has been shown that HRQOL in PD is worse than in many chronic conditions.[12],[13]

In this study, 87% of the caregivers were female, slightly higher than previously reported. In middle- to low-income countries, caregiving is considered the primary job of wives and daughters due to various socio-economic reasons. However, this is in line with previous studies in that most of the caregivers were female.[14],[15] Additionally, only 11% of the caregivers in our study were formally educated about the disease, depicting the scarcity of healthcare facilities in developing nations. Social groups were virtually absent in part because of the ongoing pandemic caused by SARS-COV-2 and poor resources. Thus, almost the entire disease burden is borne by caregivers with a limited understanding of the disease. This, in part, is reflected in our study results showing that 68% of the patients experience caregiver burden; among them, 17% perceived moderate to severe burden. Previous studies had shown considerable variation in the prevalence of caregiver burden. Studies done in high-income countries had shown less caregiver burden than studies in low- to middle-income countries. A study done in Australia reported no caregiver burden, whereas done in the UK has shown 40% felt a caregiver burden.[14],[15] NPI total score and its subdomain of psychosis impact the caregivers the most. We also found that poorer HRQOL of patents as assessed by PDQ-39 significantly affects the caregiver burden. Other significant factors associated with worse caregiver burden were the disease's H and Y scale, and duration. In a previous study; with PD progression, caregivers had to spend more time with the patient, and their burden increased and significantly impacted their health.[12] In middle- to low-income countries, a joint family is a common way of living where many related people live under the same roof. This, in part, is reflected in our study, where 43.8% of the PD patients had more than two caregivers.

Our result showed that more caregiver number was associated with decreased perception of caregiver burden. Thus, the caregiving of a patient with a chronic illness like Parkinson's requires a joint effort of family members, society, and healthcare infrastructure to provide optimum care.[16]

Depression was reported by 55% of the caregivers, and 18% fell in the moderate to severe category. Previously, depression in caregivers had been reported in the range of 28 to 44%.[10],[17],[18] A significant relationship was found between caregiver depression and H and Y stage, NPI total score, and psychotic symptoms in patients. This aligns with one study where psychiatry symptoms, falls, and disability was most closely associated with caregiver depression.[10] However, most of the studies on this subject highlighted anxiety and depression as the most significant factor.[16],[19],[20]

During the study, we found that many patients and their caregivers require urgent intervention due to the non-diagnosis of neuropsychiatric symptoms. According to a previous study, in more than 50% of outpatient department consultations, non-motor symptoms were not identified by neurologists.[21] This number became much higher if we included general practitioners. To provide holistic care to the patient, we must use HRQOL evaluations to assess multiple dimensions of the patient and aid in the overall understanding of the patient. For example, the PDQ-39 questionnaire covered eight dimensions of patient care and provided a comprehensive assessment of patient status, raising concerns that may otherwise go unnoticed.

This study has several strengths and limitations. The major strength was excluding the patient from taking antipsychotics, antidepressants, and anxiolytics. These drugs can lead to improvement in symptoms in some of the patients leading to a lesser NPI-12 score. Additionally, the study has an appropriate sample size for assessing neuropsychiatric symptoms, as most of the studies from middle to low-income countries lack suitable sample sizes.[22],[23] Furthermore, the study focuses on caregivers considering their detailed demographics, caregiver burden, and depression. A major limitation of our study is that it is a single-center, cross-sectional study, and thus, the generalization of results is limited. Also, we did not examine the impact of cognitive symptoms on caregiver burden, which in previous studies significantly impacted it. Another possible limitation is the use of only scales to assess patients and caregivers; impulse control disorders may not be captured in NPI-12. A detailed psychological examination will be more appropriate. Our study only included the patients that can attend the clinic which may have led to exclusion of patients with severe disease.

In conclusion, this study showed the presence of frequent neuropsychiatric symptoms in PD patients. It has a detrimental effect on the quality of life of patients and results in a significant increase in caregiver burden and leads to depression among them. Since caregivers are an integral part of ensuring the patients' quality of life, our efforts to address these issues should go beyond medical treatment. Apart from the motor symptoms, there is an unmet need to address these issues to provide holistic care to patients and their caregivers, especially in low-resource settings.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, et al. Past, present, and future of Parkinson's disease: A special essay on the 200th anniversary of the shaking palsy. Mov Disord 2017;32:1264–310.  Back to cited text no. 1
    
2.
Mueller C, Rajkumar AP, Wan YM, Velayudhan L, Ffytche D, Chaudhuri KR, et al. Assessment and management of neuropsychiatric symptoms in Parkinson's disease. CNS Drugs 2018;32:621–35.  Back to cited text no. 2
    
3.
Barone P, Erro R, Picillo M. Quality of life and nonmotor symptoms in Parkinson's disease. Int Rev Neurobiol 2017;133:499–516.  Back to cited text no. 3
    
4.
Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci 2000;12:233–9.  Back to cited text no. 4
    
5.
Jenkinson C, Fitzpatrick R, Peto V, Greenhall R, Hyman N. The Parkinson's Disease Questionnaire (PDQ-39): Development and validation of a Parkinson's disease summary index score. Age Ageing 1997;26:353–7.  Back to cited text no. 5
    
6.
Gort AM, Mazarico S, Ballesté J, Barberá J, Gómez X, de Miguel M. [Use of Zarit scale for assessment of caregiver burden in palliative care]. Med Clin (Barc) 2003;121:132–3.  Back to cited text no. 6
    
7.
Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.  Back to cited text no. 7
    
8.
Stefani A, Högl B. Sleep in Parkinson's disease. Neuropsychopharmacol 2020;45:121–8.  Back to cited text no. 8
    
9.
Zhang Y, Ren R, Sanford LD, Yang L, Zhou J, Tan L, et al. Sleep in Parkinson's disease: A systematic review and meta-analysis of polysomnographic findings. Sleep Med Rev 2020;51:101281.  Back to cited text no. 9
    
10.
Schrag A, Taddei RN. Depression and anxiety in Parkinson's disease. Int Rev Neurobiol 2017;133:623–55.  Back to cited text no. 10
    
11.
Santos-García D, de Deus Fonticoba T, Suárez Castro E, Aneiros Díaz A, Cores Bartolomé C, Feal Panceiras MJ, et al. Quality of life and non-motor symptoms in Parkinson's disease patients with subthreshold depression. J Neurol Sci 2020;418:117109.  Back to cited text no. 11
    
12.
Balestrino R, Martinez-Martin P. Neuropsychiatric symptoms, behavioural disorders, and quality of life in Parkinson's disease. J Neurol Sci 2017;373:173–8.  Back to cited text no. 12
    
13.
Crispino P, Gino M, Barbagelata E, Ciarambino T, Politi C, Ambrosino I, et al. Gender differences and quality of life in parkinson's disease. Int J Environ Res Public Health 2020;18:E198.  Back to cited text no. 13
    
14.
Soh SE, McGinley JL, Watts JJ, Iansek R, Morris ME. Health-related quality of life of australians with Parkinson disease: A comparison with international studies. Physiother Can 2012;64:338-46.  Back to cited text no. 14
    
15.
Leroi I, McDonald K, Pantula H, Harbishettar V. Cognitive impairment in Parkinson disease: Impact on quality of life, disability, and caregiver burden. J Geriatr Psychiatry Neurol 2012;25:208-14.  Back to cited text no. 15
    
16.
Macchi ZA, Koljack CE, Miyasaki JM, Katz M, Galifianakis N, Prizer LP, et al. Patient and caregiver characteristics associated with caregiver burden in Parkinson's disease: A palliative care approach. Ann Palliat Med 2020;9(Suppl 1):S24–33.  Back to cited text no. 16
    
17.
Martínez-Martín P, Forjaz MJ, Frades-Payo B, Rusiñol AB, Fernández-García JM, Benito-León J, et al. Caregiver burden in Parkinson's disease. Mov Disord 2007;22:924–31; quiz 1060.  Back to cited text no. 17
    
18.
Lökk J. Caregiver strain in Parkinson's disease and the impact of disease duration. Eur J Phys Rehabil Med 2008;44:39–45.  Back to cited text no. 18
    
19.
Ransmayr G. [Caregiver burden in patients with Parkinson's disease]. Fortschr Neurol Psychiatr 2020;88:567–72.  Back to cited text no. 19
    
20.
Martínez-Martín P, Guerrero-Díaz MT, Frades-Payo B. [Neuropsychological disorders in Parkinson's disease: Evaluating them and their impact on the caregiver]. Rev Neurol 2004;39:639–45.  Back to cited text no. 20
    
21.
Shulman LM, Taback RL, Rabinstein AA, Weiner WJ. Non-recognition of depression and other non-motor symptoms in Parkinson's disease. Parkinsonism Relat Disord 2002;8:193–7.  Back to cited text no. 21
    
22.
Ozdilek B, Gunal DI. Motor and non-motor symptoms in Turkish patients with Parkinson's disease affecting family caregiver burden and quality of life. J Neuropsychiatry Clin Neurosc 2012;24:478–83.  Back to cited text no. 22
    
23.
Carod-Artal FJ, Mesquita HM, Ziomkowski S, Martinez-Martin P. Burden and health-related quality of life among caregivers of Brazilian Parkinson's disease patients. Parkinsonism Relat Disord 2013;19:943–8.  Back to cited text no. 23
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]



 

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