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Clinical features and outcome of stroke with COVID-19. COVID-19 stroke study group (CSSG), India


1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Neurology, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
3 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
4 Department of Neurology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India
5 Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India
6 Department of Neurology; Department of Neurointervention Surgery, Artemis Hospitals, Gurgaon, Haryana, India
7 Department of Neurology, Max Super Speciality Hospital Saket, New Delhi, India
8 Department of Neurology, Institute of Human Behaviour and Allied Sciences, Neurology, New Delhi, India
9 Department of Neurology, Institute of Neurosciences, Kolkata, West Bengal, India
10 Department of Anaesthesia, All India Institute of Medical Sciences, New Delhi, India
11 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
12 Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
13 Department of Neurointervention Surgery, Artemis Hospitals, Gurgaon, Haryana, India
14 Department of Neurology, Ramesh Hospitals Guntur, Andhra Pradesh, India
15 Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
16 Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India
17 Department of Neurology, Lalitha Super Specialty Hospital, Guntur, Andhra Pradesh, India
18 Department of Neurology, Command Hospital Air Force Bangalore, Bangalore, Karnataka, India
19 Department of Neurology, Christian Medical College, Ludhiana, Punjab, India
20 Department of Neurology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, Delhi, India
21 Department of Neurology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India
22 Department of Neurology, Zydus Hospital, Ahmedabad, Gujarat, India
23 Department of Neurology, Amrita Institute of Medical Sciences, Cochin, Kerala, India

Correspondence Address:
Rohit Bhatia,
Department of Neurology, All India Institute of Medical Sciences, New Delhi
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aian.AIAN_122_21

Background and Purpose: Occurrence of stroke has been reported among patients with COVID-19. The present study compares clinical features and outcomes of stroke patients with and without COVID-19. Methods: The COVID-19 Stroke Study Group (CSSG) is a multicentric study in 18 sites across India to observe and compare the clinical characteristics of patients with stroke admitted during the current pandemic period and a similar epoch in 2019. The present study reports patients of stroke with and without COVID-19 (CoVS and non-CoVS, respectively) seen between February 2020 and July 2020. Demographic, clinical, treatment, and outcome details of patients were collected. Results: The mean age and gender were comparable between the two groups. CoVS patients had higher stroke severity and extent of cerebral involvement on imaging. In-hospital complications and death were higher among CoVS patients (53.06% vs. 17.51%; P < 0.001) and (42.31% vs. 7.6%; P < 0.001), respectively. At 3 months, higher mortality was observed among CoVS patients (67.65% vs. 13.43%; P < 0.001) and good outcome (modified Rankin score [mRS]: 0–2) was seen more often in non-CoVS patients (68.86% vs. 33.33%; P < 0.001). The presence of COVID-19 and baseline stroke severity were independent predictors of mortality. Conclusions: CoVS is associated with higher severity, poor outcome, and increased mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and baseline stroke severity are independent predictors of mortality.


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    -  Bhatia R
    -  Padma Srivastava M V
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    -  Pardasani V
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