Annals of Indian Academy of Neurology
  Users Online: 827 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
Ahead of Print

Semantic fluency predicts gait velocity in PSP

 Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, West Bengal, India

Correspondence Address:
Hrishikesh Kumar,
Department of Neurology, Institute of Neurosciences Kolkata, 185/1 AJC Bose Road, Kolkata - 700 017, West Bengal
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aian.AIAN_71_21

Context: Progressive supranuclear palsy (PSP) is a large-scale network disease resulting in variable signs and symptoms including gait impairment and higher order cognitive dysfunction. Despite few studies showing the association of falls and cognitive dysfunction, the existing literature is yet to establish the exact relationship of discrete characteristics of gait with cognitive function in PSP. Aims: In this cross-sectional study, we aimed to characterize and explore the relationship of these two apparently distinct physiological phenomena in patients with PSP and across its different variants. Methods and Material: Quantitative assessment of two-dimensional gait parameters was measured using an electronic walkway (GAITRite®). Dementia Rating Scale-2 was used to assess global as well as higher order cognitive functions. Statistical Analysis Used: A regression model was used to interpret results. Results: We observed that the variability domain of gait was significantly impaired in PSP patients with severe cognitive impairment compared to that of intact cognition. Moreover, initiation/perseveration (I/P), a higher order cognitive process, and one of its specific components, i.e., complex verbal task (β = 2.39, P < 0.001), significantly predict gait velocity in PSP [F (1, 40) = 16.102, P < 0.001]. Conclusions: Our findings indicate that the severity of cognitive functions affects gait variability, which might lead to frequent falls as observed in PSP. Furthermore, semantic fluency task of I/P function may act as a predictor of gait velocity. We suspect that higher order cognitive dysfunction through the damage of frontal lobe structure including dorsolateral prefrontal cortex or related network may influence gait in PSP.

Print this article
 Table of Contents

  Search Pubmed for
    -  Chatterjee K
    -  Choudhury S
    -  Siddique U
    -  Mondal B
    -  Kulsum MU
    -  Haldar S
    -  Basu P
    -  Banerjee R
    -  Kumar H
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded11    

Recommend this journal