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Paraneoplastic syndromes in neuro-ophthalmology
Simon J Hickman
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Correspondence Address:
Simon J Hickman,
Department of Neurology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF
UK
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/aian.aian_102_22
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Paraneoplastic neurological syndromes (PNS) occur in about 1 in 300 cases of cancer. The usual mechanism is that an antigen on the cancer sets off an immune response that then cross-reacts with a nervous system antigen. The presentation is usually with a subacute progressive neurological disorder. The management of these conditions is usually of both the underlying tumor and immunomodulation to suppress the autoimmune response. There are a number of these conditions that can present to the Neuro-Ophthalmology clinic, either as a discrete condition affecting vision or eye movements or as part of a more widespread neurological disorder. This article will discuss these conditions, their management and prognosis.
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