Relevance of geographical and biochemical factors in causation of cerebral venous sinus thrombosis: An observational analytical study Varsha A Prabhu1, Sankar Prasad Gorthi2, Nilima3, Sai Sripad Rao4, Radhika Nair5, Magith Thambi1, Ashwini Naik5


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Relevance of geographical and biochemical factors in causation of cerebral venous sinus thrombosis: An observational analytical study Varsha A Prabhu¹, Sankar Prasad Gorthi², Nilima³, Sai Sripad Rao⁴, Radhika Nair⁵, Magith Thambi¹, Ashwini Naik⁵ ¹ Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE); Department f Neurology, Kasturba Hospital, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India ² Department of Neurology, Kasturba Hospital, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka; Department of Neurology, Bharati Vidyapeeth Medical College, Pune, Maharashtra, India ³ Department of Statistics, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka; Indian Institute of Public Health, Scientist-I Department of Biostatistics, All India Institute of Medical Sciences, Delhi, India ⁴ Department of Neurology, Kasturba Hospital, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka; HOPE Hospital, Nizambad, Telangana, India ⁵ Department of Neurology, Kasturba Hospital, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India Correspondence Address: Sankar Prasad Gorthi, Department of Neurology, Bharati Vidhyapeeth Medical College, Pune, Maharashtra India Source of Support: None, Conflict of Interest: None DOI: 10.4103/aian.aian_1109_21

Objectives: There is a higher prevalence of cerebral venous sinus thrombosis (CVST) in more recent times, owing to increased awareness, clinical diagnostic skills, and advancements in neuroimaging modalities. This study aimed to identify and characterize the geographical, clinical, and etiological profiles of patients with CVST that may be relevant to planning appropriate diagnostic and therapeutic strategies to improve functional recovery. Methods and Results: A retrospective observational study was carried out at a tertiary care hospital between March 2014 and October 2018. The demographics and clinical profile of the hospitalized patients were extracted from the Medical Record Division. Choropleth maps were created to present the geographic distribution of the patients with CVST admitted to our hospital. A total of 145 patients with CVST were included in the study. Etiological factors revealed striking abnormalities in red blood cells counts and serum homocysteine. Analyzing the geographical distribution of the patients with CVST showed most of the patients hailed from Central Karnataka Plateau 106 (73%). Polycythemia was most commonly seen in patients residing in the Central Karnataka Plateau 21 (62%). Conclusion: It is inferred that large scale community-based studies to identify a genetic abnormality like a mutant erythropoietin gene should be undertaken to plan effective diagnostic, therapeutic, and preventive measures.

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    -  Prabhu VA
    -  Gorthi SP
    -  Nilima
    -  Rao SS
    -  Nair R
    -  Thambi M
    -  Naik A

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