Annals of Indian Academy of Neurology
CASE REPORT
Year
: 2006  |  Volume : 9  |  Issue : 3  |  Page : 172--174

Vanishing white matter disease: Phenotypic, MR imaging and 1H spectroscopic observations


S Ravishankar1, S Sinha2, AB Taly2, J Panicker2 
1 Department of Neuroimaging and Interventional Neuroradiology, National Institute of Mental Health and Neurosciences, Bangalore, India
2 Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India

Correspondence Address:
S Sinha
National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore - 560 029
India

We report MR imaging features of vanishing white matter disease in a 7-year-old boy, who manifested with seizures, aphasia, spastic quadriparesis and myoclonic jerks. MRI of brain showed diffuse white matter signal changes of CSF intensity in all the sequences. MR spectroscopy of white matter showed severe decrease in NAA, choline and creatine and presence of lactate peak. Additional notable findings were diffuse extensive brain stem and thalamic atrophy. The clinico-radiological correlation was consistent with the diagnosis of vanishing white matter disease. Reporting of such cases may widen the spectra of these disorders.


How to cite this article:
Ravishankar S, Sinha S, Taly A B, Panicker J. Vanishing white matter disease: Phenotypic, MR imaging and 1H spectroscopic observations.Ann Indian Acad Neurol 2006;9:172-174


How to cite this URL:
Ravishankar S, Sinha S, Taly A B, Panicker J. Vanishing white matter disease: Phenotypic, MR imaging and 1H spectroscopic observations. Ann Indian Acad Neurol [serial online] 2006 [cited 2021 Jan 25 ];9:172-174
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2006;volume=9;issue=3;spage=172;epage=174;aulast=Ravishankar;type=0