Annals of Indian Academy of Neurology
: 2008  |  Volume : 11  |  Issue : 3  |  Page : 140--145

Autoantibodies in neuromuscular transmission disorders

Angela Vincent 
 Department of Clinical Neurology and Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom

Correspondence Address:
Angela Vincent
Department of Clinical Neurology, West Wing, John Radcliffe Hospital, Oxford OX3 9DU
United Kingdom

It is a great pleasure to be asked to honour the memory of Dr. Baldev Singh by reviewing the field of autoantibodies in myasthenia gravis and other neurotransmission disorders. The neuromuscular junction (NMJ) is the site of a number of different autoimmune and genetic disorders, and it is also the target of many neurotoxins from venomous snakes, spiders, scorpions and other species. The molecular organization of the NMJ is graphically represented in [Figure 1A], where different ion channels, receptors and other proteins are shown. Four of the ion channels or receptors are directly involved in autoimmune diseases. This brief review will not only concentrate on these conditions but also illustrate how their study is helping us to understand the etiology of rare but treatable neurological syndromes of the central nervous system.

How to cite this article:
Vincent A. Autoantibodies in neuromuscular transmission disorders.Ann Indian Acad Neurol 2008;11:140-145

How to cite this URL:
Vincent A. Autoantibodies in neuromuscular transmission disorders. Ann Indian Acad Neurol [serial online] 2008 [cited 2021 Nov 28 ];11:140-145
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