Annals of Indian Academy of Neurology
REVIEW ARTICLE
Year
: 2009  |  Volume : 12  |  Issue : 1  |  Page : 3--11

Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders


Abhilash Venugopal1, Raghothama Chaerkady2, Akhilesh Pandey3 
1 Institute of Bioinformatics, Bangalore 560 066,India
2 Institute of Bioinformatics, Bangalore 560 066,India; McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA
3 McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA

Correspondence Address:
Akhilesh Pandey
527 Broadway Research Building, 733 N. Broadway, Baltimore, MD 21205, USA

Mass spectrometry-based quantitative proteomics has emerged as a powerful approach that has the potential to accelerate biomarker discovery, both for diagnostic as well as therapeutic purposes. Proteomics has traditionally been synonymous with 2D gels but is increasingly shifting to the use of gel-free systems and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Quantitative proteomic approaches have already been applied to investigate various neurological disorders, especially in the context of identifying biomarkers from cerebrospinal fluid and serum. This review highlights the scope of different applications of quantitative proteomics in understanding neurological disorders with special emphasis on biomarker discovery.


How to cite this article:
Venugopal A, Chaerkady R, Pandey A. Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders.Ann Indian Acad Neurol 2009;12:3-11


How to cite this URL:
Venugopal A, Chaerkady R, Pandey A. Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders. Ann Indian Acad Neurol [serial online] 2009 [cited 2021 Jan 18 ];12:3-11
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2009;volume=12;issue=1;spage=3;epage=11;aulast=Venugopal;type=0