Annals of Indian Academy of Neurology
REVIEW: PROGRESS IN MEDICINE
Year
: 2009  |  Volume : 12  |  Issue : 4  |  Page : 221--225

B cells as a target of immune modulation


Kathleen Hawker 
 The Ohio State University Medical Center, 2050 Kenny Road, Suite 2250, Columbus, Ohio 43221, USA

Correspondence Address:
Kathleen Hawker
The Ohio State University Medical Center, 2050 Kenny Road, Suite 2250, Columbus, Ohio 43221
USA

B cells have recently been identified as an integral component of the immune system; they play a part in autoimmunity through antigen presentation, antibody secretion, and complement activation. Animal models of multiple sclerosis (MS) suggest that myelin destruction is partly mediated through B cell activation (and plasmablasts). MS patients with evidence of B cell involvement, as compared to those without, tend to have a worse prognosis. Finally, the significant decrease in new gadolinium-enhancing lesions, new T2 lesions, and relapses in MS patients treated with rituximab (a monoclonal antibody against CD20 on B cells) leads us to the conclusion that B cells play an important role in MS and that immune modulation of these cells may ameliorate the disease. This article will explore the role of B cells in MS and the rationale for the development of B cell-targeted therapeutics. MS is an immune-mediated disease that affects over 2 million people worldwide and is the number one cause of disability in young patients. Most therapeutic targets have focused on T cells; however, recently, the focus has shifted to the role of B cells in the pathogenesis of MS and the potential of B cells as a therapeutic target.


How to cite this article:
Hawker K. B cells as a target of immune modulation.Ann Indian Acad Neurol 2009;12:221-225


How to cite this URL:
Hawker K. B cells as a target of immune modulation. Ann Indian Acad Neurol [serial online] 2009 [cited 2021 Oct 27 ];12:221-225
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2009;volume=12;issue=4;spage=221;epage=225;aulast=Hawker;type=0