Annals of Indian Academy of Neurology
CASE REPORT
Year
: 2010  |  Volume : 13  |  Issue : 2  |  Page : 142--144

Familial amyloidotic polyneuropathy with muscle, vitreous, leptomeningeal, and cardiac involvement: Phenotypic, pathological, and MRI description


DK Prashantha1, Arun B Taly1, Sanjib Sinha1, T Chikkabasavaiah Yasha2, Narayanappa Gayathri2, J. M. E Kovur1, Joy Vijayan1 
1 Departments of Neurology, Neuroimaging and Interventional Radiology, NIMHANS, Bangalore, India
2 Department of Neuropathology, NIMHANS, Bangalore, India

Correspondence Address:
Arun B Taly
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore - 560 029
India

Familial amyloidotic polyneuropathy (FAN type 1) is a rare systemic disease that causes severe and disabling peripheral neuropathy. We describe the phenotypic, radiological, and pathological characteristics of a patient with familial amyloid polyneuropathy type 1 who had evidence of motor-sensory-autonomic neuropathy, ocular vitreous deposits, diffuse leptomeningeal involvement, and hypertrophic cardiomyopathy. Muscle involvement, an infrequently reported feature, was also observed. Early recognition of the disease has significant therapeutic implications.


How to cite this article:
Prashantha D K, Taly AB, Sinha S, Yasha T C, Gayathri N, Kovur J, Vijayan J. Familial amyloidotic polyneuropathy with muscle, vitreous, leptomeningeal, and cardiac involvement: Phenotypic, pathological, and MRI description.Ann Indian Acad Neurol 2010;13:142-144


How to cite this URL:
Prashantha D K, Taly AB, Sinha S, Yasha T C, Gayathri N, Kovur J, Vijayan J. Familial amyloidotic polyneuropathy with muscle, vitreous, leptomeningeal, and cardiac involvement: Phenotypic, pathological, and MRI description. Ann Indian Acad Neurol [serial online] 2010 [cited 2021 Jan 17 ];13:142-144
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2010;volume=13;issue=2;spage=142;epage=144;aulast=Prashantha;type=0