Annals of Indian Academy of Neurology
ORIGINAL ARTICLE
Year
: 2016  |  Volume : 19  |  Issue : 3  |  Page : 339--343

Polycystic ovary syndrome in patients on antiepileptic drugs


Lakshminarayanapuram G Viswanathan1, Parthasarathy Satishchandra1, Bipin C Bhimani1, Janardhan YC Reddy2, Batchu S Rama Murthy3, Doddaballapura K Subbakrishna4, Sanjib Sinha1 
1 Department of Neurology, NIMHANS, Bengaluru, Karnataka, India
2 Department of Psychiatry, NIMHANS, Bengaluru, Karnataka, India
3 Srinivasa Ultrasound Scan Center, Shankarpuram, Bengaluru, Karnataka, India
4 Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India

Correspondence Address:
Parthasarathy Satishchandra
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru - 560 029, Karnataka
India

Objective: This study aims to discuss the prevalence of polycystic ovary (PCO) and Polycystic ovary syndrome (PCOS) in women with epilepsy (WWE) on valproate (VPA), carbamazepine (CBZ), or phenobarbitone (PB), drug naive WWE and women with bipolar affective disorder (BPAD) on VPA. Materials and Methods: This prospective study included 190 women aged 18-45 years, who had epilepsy or BPAD (on VPA), and consented for study. Patients were grouped as Group 1 (n = 40): WWE on VPA, Group 2 (n = 50): WWE on CBZ, Group 3 (n = 50): WWE on PB, Group 4 (n = 30): drug naοve WWE, and Group 5 (n = 20): women with BPAD on VPA. All women were interviewed for medical, menstrual, drug and treatment history, nature of epilepsy, and seizure control. Chi-square test and Fisher«SQ»s exact test were done to compare results between the groups. Results: Fifty-two women (52/190; 27.4%) had menstrual disturbances, in which oligomenorrhea was the most common (55.8%). There was a significant difference in the occurrence of PCOS in patients on VPA versus normal population (P = 0.05) and patients on other antiepileptic drugs (AEDs) (P = 0.02). There was, however, no significant difference in the occurrence of PCO between patients on VPA and the untreated epileptic women. VPA group (Epilepsy + BPAD) had a significantly higher occurrence of obesity than other treatment groups (P = 0.043, OR = 2.11). Conclusions: The study observed significantly higher occurrence of PCO in patients on VPA compared to other AEDs and the normal population. The importance of proper clinical evaluation before initiating VPA is highlighted.


How to cite this article:
Viswanathan LG, Satishchandra P, Bhimani BC, Reddy JY, Rama Murthy BS, Subbakrishna DK, Sinha S. Polycystic ovary syndrome in patients on antiepileptic drugs.Ann Indian Acad Neurol 2016;19:339-343


How to cite this URL:
Viswanathan LG, Satishchandra P, Bhimani BC, Reddy JY, Rama Murthy BS, Subbakrishna DK, Sinha S. Polycystic ovary syndrome in patients on antiepileptic drugs. Ann Indian Acad Neurol [serial online] 2016 [cited 2021 Sep 28 ];19:339-343
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=3;spage=339;epage=343;aulast=Viswanathan;type=0