Annals of Indian Academy of Neurology
ORIGINAL ARTICLE
Year
: 2020  |  Volume : 23  |  Issue : 3  |  Page : 270--274

Prevalence of non-motor symptoms in Parkinson's disease and its impact on quality of life in tertiary care center in India


Madhavi Karri1, Balakrishnan Ramasamy1, Ramadoss Kalidoss2 
1 Department of Neurology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
2 Department of Neurology, Sri Ramakrishna Hospitals, Coimbatore, Tamil Nadu, India

Correspondence Address:
Dr. Balakrishnan Ramasamy
Department of Neurology, PSG Institute of Medical Sciences and Research, PSG Hospitals, Peelamedu, Coimbatore, Tamil Nadu - 641 004
India

Context: Parkinson's disease (PD) is a neurodegenerative disease characterized by traditional motor features. Non-motor symptoms (NMS) are also seen in PD, which inevitably emerge through the disease progression and are often under-recognized and untargeted. Aims: We studied the prevalence of NMS in PD and their impact on health-related quality of life (HRQoL). Materials and Methods: A cross-sectional observational study from January 2017 to July 2017 of PD patients (n = 100) was done. NMS and HRQoL are measured using NMS scoring scale; PD questionnaire-39 and Hoehn and Yahr scale, respectively. Motor symptoms were assessed using scales for outcome in Parkinson's disease (SCoPA) - motor scoring scale. Statistical Analysis: Descriptive statistics calculated for NMS' prevalence. Continuous variables were assessed by two-tailed t-test and discrete and categorical variables by chi-square test. Multiple linear regression analysis was done among scoring scales to identify the influence on 39-item Parkinson's disease questionnaire (PDQ-39) scoring scale. All statistical data collected are analyzed with SSPS software version- 20 for windows. Results: In 100 study population, 66 were males and 34 females. The mean age was 68.35 years and median onset of duration of PD was 3.49 with 64.6% on treatment. Fatigue, pain, and lightheadedness were more prevalent NMS with 78%, 75%, and 69%, respectively. With regression analysis, strongest predictor was NMSS score (P = 0.000), with each unit increase, it is associated with nearly 0.65 increase in PDQ-39 score. Conclusion: Though motor symptoms define the disease, NMS have a larger impact on HRQoL in PD and on caregiver's life. Understanding the pattern and effect of NMS is needed for targeted treatment strategies.


How to cite this article:
Karri M, Ramasamy B, Kalidoss R. Prevalence of non-motor symptoms in Parkinson's disease and its impact on quality of life in tertiary care center in India.Ann Indian Acad Neurol 2020;23:270-274


How to cite this URL:
Karri M, Ramasamy B, Kalidoss R. Prevalence of non-motor symptoms in Parkinson's disease and its impact on quality of life in tertiary care center in India. Ann Indian Acad Neurol [serial online] 2020 [cited 2022 Sep 26 ];23:270-274
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=3;spage=270;epage=274;aulast=Karri;type=0