Annals of Indian Academy of Neurology
ORIGINAL ARTICLE
Year
: 2020  |  Volume : 23  |  Issue : 4  |  Page : 522--527

Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy


Sanjith Aaron1, Jeyaseelan Lakshmanan2, Thambu D Sudarsanam3, Kenneth Benjamin4, Jothilakshmi Durairaj2, Vivek Mathew1, Ajith Sivadasan1, AT Prabhakar4, Shyam Kumar N. Keshava4, Pavitra R Mannam4, Prabhu Kirubakaran1, Jayaprakash Muliyil5, Mathew Alexander1 
1 Department of Neurology, Christian Medical College Hospital, Vellore, Tamil Nadu, India
2 Department of Biostatistics, Christian Medical College Hospital, Vellore, Tamil Nadu, India
3 Department of General Medicine, Christian Medical College Hospital, Vellore, Tamil Nadu, India
4 Department of Radiology, Christian Medical College Hospital, Vellore, Tamil Nadu, India
5 Department of Community Medicine, Christian Medical College Hospital, Vellore, Tamil Nadu, India

Correspondence Address:
Sanjith Aaron
Department of Neurology, Christian Medical College, Vellore, Tamil Nadu - 632004
India

Background and Purpose: Studies looking at seasonal variation on cerebral venous thrombosis (CVT) are few with conflicting conclusions. In this region-specific study, we looked for climatic influence and seasonal trends on the incidence of CVT. Methods: Imaging proven adult CVT cases treated over a period of 18 years from a specific geographical location with similar seasons and climatic conditions were studied. Metrological parameters prepared using 30 years of data was used. Quantum geographical information system (QGIS software) and SPSS v 22 were used for patient plotting and analysis. Results: Total of 970 cases were studied. The incidence was significantly higher in summer 411 (42.3%) compared with autumn 317 (32.7%) and winter 242 (25.05); P = 0.038. This trend was consistent across all the 18 years in time series analysis. Mean age was 33.5 years (range 18–88 years). A significant majority 673 (69.4%) were below 40 years of age; P = 0.012. Females constituted 394 (40.6%) of cases. Postpartum CVT cases constituted 237 (30%). Interaction analysis showed younger age (<40 years) were more vulnerable for CVT in summer; P = 0.009. There was no seasonal influence on postpartum CVT. Apart for a weak positive correlation between rain fall (r = 0.18, P < 0.01); humidity and cloud cover was not influencing the incidence. Conclusions: Higher ambient temperatures were consistently associated with higher incidence of CVT. This is the largest region-specific study on CVT in the world. These results may be applicable to other regions with similar climatic conditions.


How to cite this article:
Aaron S, Lakshmanan J, Sudarsanam TD, Benjamin K, Durairaj J, Mathew V, Sivadasan A, Prabhakar A T, N. Keshava SK, Mannam PR, Kirubakaran P, Muliyil J, Alexander M. Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy.Ann Indian Acad Neurol 2020;23:522-527


How to cite this URL:
Aaron S, Lakshmanan J, Sudarsanam TD, Benjamin K, Durairaj J, Mathew V, Sivadasan A, Prabhakar A T, N. Keshava SK, Mannam PR, Kirubakaran P, Muliyil J, Alexander M. Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy. Ann Indian Acad Neurol [serial online] 2020 [cited 2021 Apr 17 ];23:522-527
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=4;spage=522;epage=527;aulast=Aaron;type=0