Annals of Indian Academy of Neurology
ORIGINAL ARTICLE
Year
: 2022  |  Volume : 25  |  Issue : 3  |  Page : 473--478

Significance of neuronal autoantibodies in comparison to infectious etiologies among patients presenting with encephalitis in a region with a high prevalence of infections


Thashi Chang1, Teresa Moloney2, Leslie Jacobson2, Neelika Malavige3, Janarthani Lohitharajah4, Jithangi Wanigasinghe5, Sian Peach2, Mark Woodhall2, Antonio Berretta2, Patrick Waters2, Angela Vincent2 
1 Department of Clinical Medicine, University of Colombo, Sri Lanka
2 Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
3 Department of Immunology, University of Sri Jayawardenapura, Sri Lanka
4 Department of Pathophysiology, Eastern University, Sri Lanka
5 Department of Paediatrics, University of Colombo, Sri Lanka

Correspondence Address:
Thashi Chang
Department of Clinical Medicine, Faculty of Medicine – University of Colombo, 25, Kynsey Road, Colombo - 00800
Sri Lanka

Background: Prevalence of antibody-mediated autoimmune encephalitis (AE) is reported to be comparable to infectious encephalitis in Western populations. We evaluated the frequency and significance of AE and neuronal autoantibodies in comparison to infectious etiologies among patients presenting with encephalitis in a South Asian population. Methods: Ninety-nine consecutive patients with a clinical diagnosis of encephalitis/meningoencephalitis admitted to two of the largest tertiary-care hospitals in Sri Lanka were studied. PCR and ELISA were used to screen viruses while Gram stain and culture were used to screen bacteria. Sera were tested for antibodies binding to primary embryonic rat hippocampal neuronal cultures and cell-based assays for antibodies to NMDAR, LGI1, CASPR2, Contactin2, AMPAR, GABAAR, GABABR, aquaporin-4 and MOG. Results: Patient ages ranged from 1 month to 73 years (mean = 24.91; SD = 21.33) with a male: female ratio of 1.75:1. A viral etiology was identified in 27.3% and bacterial meningoencephalitis was diagnosed in 17.1%. Sera of nine patients had antibodies binding to live primary neurons, but only five had specific antibodies to CASPR2 (n = 1), NMDAR (n = 2) or GABABR-antibodies (n = 2). Moreover, the patients with CASPR2 antibodies and NMDAR-antibodies were also positive for dengue antibodies. Only the two patients with NMDAR-antibodies had features and responses to immunotherapy consistent with AE. Conclusions: Identified infectious forms of meningoencephalitis (44.4%) greatly exceeded the occurrence of neuronal autoantibodies (9.1%) and AE (2%) in Sri Lanka, and this may be common in those regions where infections are prevalent.


How to cite this article:
Chang T, Moloney T, Jacobson L, Malavige N, Lohitharajah J, Wanigasinghe J, Peach S, Woodhall M, Berretta A, Waters P, Vincent A. Significance of neuronal autoantibodies in comparison to infectious etiologies among patients presenting with encephalitis in a region with a high prevalence of infections.Ann Indian Acad Neurol 2022;25:473-478


How to cite this URL:
Chang T, Moloney T, Jacobson L, Malavige N, Lohitharajah J, Wanigasinghe J, Peach S, Woodhall M, Berretta A, Waters P, Vincent A. Significance of neuronal autoantibodies in comparison to infectious etiologies among patients presenting with encephalitis in a region with a high prevalence of infections. Ann Indian Acad Neurol [serial online] 2022 [cited 2022 Sep 27 ];25:473-478
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=3;spage=473;epage=478;aulast=Chang;type=0