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Figure 2: Spectrum of antisynthetase syndrome and antibodies. Jo-1 antibody is the commonest antibody associated with antisynthetase syndrome. Anti-EJ and PL-7 may present with classic DM. 60-70% of anti- OJ and anti-KS present as ILD alone. Anti-MDA5 is associated with severe necrotizing skin lesions and rapidly progressive ILD. Abbreviations: ILD: interstitial lung disease, DM: dermatomyositis, CADM: clinically amyopathic dermatomyositis

Figure 2: Spectrum of antisynthetase syndrome and antibodies. Jo-1 antibody is the commonest antibody associated with antisynthetase syndrome. Anti-EJ and PL-7 may present with classic DM. 60-70% of anti- OJ and anti-KS present as ILD alone. Anti-MDA5 is associated with severe necrotizing skin lesions and rapidly progressive ILD. Abbreviations: ILD: interstitial lung disease, DM: dermatomyositis, CADM: clinically amyopathic dermatomyositis