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Figure 2: MRI images of proband and II-1. Left three columns: Proband at the age of 45, 48, 51. Right column: II-1 at the age of 55. First line: T2-weighted images. Second line: FLAIR images. Third line: T1-weighted image (A 45y), 3D time of flight image (A 48y, B 55y), gradient-echo image (A 51y). Multifocal cerebral infarction (yellow arrow). White matter hyperintensities (white arrow) involve corona radiata, bilateral periventricular and corpus callosum. Microbleeds (red arrow). No atherostenosis are detected

Figure 2: MRI images of proband and II-1. Left three columns: Proband at the age of 45, 48, 51. Right column: II-1 at the age of 55. First line: T2-weighted images. Second line: FLAIR images. Third line: T1-weighted image (A 45y), 3D time of flight image (A 48y, B 55y), gradient-echo image (A 51y). Multifocal cerebral infarction (yellow arrow). White matter hyperintensities (white arrow) involve corona radiata, bilateral periventricular and corpus callosum. Microbleeds (red arrow). No atherostenosis are detected