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Figure 3: α-Dystroglycanopathy (a-e): H and E showing features of muscular dystrophy (a). Partial loss/reduced expression of laminin α2 (b). Preserved expression on collagen VI (A1,2,3) (c) and laminin γ1 (d). Western blot (e) showing absence of band at 156 kDa in test on staining with primary antibody for α-dystroglycan (α-DG). Walker–Warburg syndrome (f-j): H and E showing features of muscular dystrophy (f). Preserved expression of laminin α2 (g), collagen VI (A1,2,3) (h), and laminin γ1 (i). Western blot (j) showing absence of band at 85 kDa to POMT1 and reduced α-dystroglycan (α-DG; 156 kDa) expression

Figure 3: α-Dystroglycanopathy (a-e): H and E showing features of muscular dystrophy (a). Partial loss/reduced expression of laminin α2 (b). Preserved expression on collagen VI (A1,2,3) (c) and laminin γ1 (d). Western blot (e) showing absence of band at 156 kDa in test on staining with primary antibody for α-dystroglycan (α-DG). Walker–Warburg syndrome (f-j): H and E showing features of muscular dystrophy (f). Preserved expression of laminin α2 (g), collagen VI (A1,2,3) (h), and laminin γ1 (i). Western blot (j) showing absence of band at 85 kDa to POMT1 and reduced α-dystroglycan (α-DG; 156 kDa) expression